Harvard Scientists Discover That Cold Temperatures Could Help You Lose Weight

Obesity Weight Loss Concept

Harvard Scientists Uncover That Chilly Temperatures Might Assist You Lose Weight

Researchers have discovered that by decreasing irritation, chilly temperatures might help battle weight problems and associated metabolic illnesses.

Brown adipose tissue is activated by chilly to launch anti-inflammatory compounds.

Greater than 40% of American adults are overweight, an advanced situation that will increase the danger of diabetes, coronary heart illness and a number of other kinds of most cancers. By creating power low-grade irritation and the buildup of immune cells in insulin-sensitive tissues, weight problems is an element that may contribute to different well being points. Scientists imagine that reversing or “resolving” this power irritation might delay the onset of obesity-related illnesses like diabetes and presumably facilitate weight reduction.

Researchers from Brigham and Girls’s Hospital and Joslin Diabetes Middle discovered that in diet-induced overweight mice, publicity to chilly temperatures improved insulin sensitivity and glucose tolerance whereas resolving irritation induced by weight problems. Their findings have been reported in a brand new paper printed in Pure metabolism.

The analysis workforce additionally found that the mechanism was depending on brown adipose tissue, generally known as “good fats”, releasing a naturally occurring molecule referred to as Maresin 2 in response to chilly stimulation. Brown adipose tissue is named an lively endocrine organ as a result of it secretes molecules that talk with different tissues and handle metabolism. It additionally helps launch saved power and should help weight discount and metabolic well being.

“Ample proof signifies that weight problems and metabolic syndrome are linked to power irritation that results in systemic insulin resistance, so interrupting irritation in weight problems might provide promising therapies for the illnesses associated to weight problems,” stated co-corresponding creator Yu-Hua Tseng, Ph.D., senior researcher within the Part of Integrative Physiology and Metabolism on the Joslin Diabetes Middle and professor of medication at Harvard Medical Faculty.

“We discovered that chilly publicity decreased irritation and improved metabolism in weight problems, mediated at the very least partially by activation of brown adipose tissue. These outcomes recommend a beforehand unrecognized operate of brown adipose tissue in selling irritation decision in weight problems.

In two earlier experiments, Tseng and his colleagues discovered that brown fats may be activated by publicity to chilly to create sure lipid mediators that management nutrient metabolism. Within the present examine, researchers recognized a novel position for a lipid mediator produced from brown fats to resolve irritation.

Within the present examine, the researchers created a mouse mannequin that, when fed a typical high-fat Western weight-reduction plan, developed weight problems.

When animals have been uncovered to a chilly atmosphere (roughly 40 levels[{” attribute=””>Fahrenheit), the researchers observed that the animals’ insulin sensitivity and glucose metabolism improved and their body weight decreased, compared to control animals maintained at a thermoneutral zone – the environmental temperature where the body does not need to produce heat for maintaining its core body temperature.

What’s more, the scientists also noticed a profound improvement in inflammation, as measured by reduced levels of a major inflammatory marker.

“We found that brown fat produces Maresin 2, which resolves inflammation systemically and in the liver,” said co-corresponding author Matthew Spite, Ph.D., a lead investigator at Brigham and Women’s Hospital and Associate Professor of Anesthesia at Harvard Medical School. “These findings suggest a previously unrecognized function of brown adipose tissue in promoting the resolution of inflammation in obesity via the production of this important lipid mediator.”

Moreover, these findings also suggest that Maresin 2 could have clinical applications as a therapy for patients with obesity, metabolic disease, or other diseases linked to chronic inflammation; however, the molecule itself breaks down quickly in the body. Tseng and colleagues seek a more stable chemical analog for clinical use.

The team notes a shortcut to improved metabolic health may already exist. Multiple human studies conducted at Joslin and elsewhere show that exposure to mildly cold temperatures (50 to 55 degrees Fahrenheit) has been shown to be sufficient to activate brown adipose tissue and improve metabolism, though the mechanisms are not well understood.

Reference: “Brown adipose tissue-derived MaR2 contributes to cold-induced resolution of inflammation” by Satoru Sugimoto, Hebe Agustina Mena, Brian E. Sansbury, Shio Kobayashi, Tadataka Tsuji, Chih-Hao Wang, Xuanzhi Yin, Tian Lian Huang, Joji Kusuyama, Sean D. Kodani, Justin Darcy, Gerson Profeta, Nayara Pereira, Rudolph E. Tanzi, Can Zhang, Thomas Serwold, Efi Kokkotou, Laurie J. Goodyear, Aaron M. Cypess, Luiz Osório Leiria, Matthew Spite, and Yu-Hua Tseng, 27 June 2022, Nature Metabolism.
DOI: 10.1038/s42255-022-00590-0

This work was supported in part by US National Institutes of Health (NIH) grants (R01DK122808, R01DK077097, R01DK102898, R01HL106173, R01DK099511, R01DK112283, P30DK0368360) and by US Army Medical Research grant W81XWH-17-1-0428; the Manpei Suzuki Diabetes Foundation in Japan; grant 2019/20554-7 from The São Paulo Research Foundation, FAPESP; an American Diabetes Association post-doctoral fellowship (1-16-PDF-063); the Sao Paulo Research Foundation (FAPESP) grants 2017/02684 and 2019/26008-4.

Spite and Tseng are inventors of a pending provisional patent application related to Maresin 2 and metabolic therapeutics.


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